Cefotil Plus 500 Tablet is an antibiotic consisting of (Cefuroxime Axetil 500mg + Clavulanic Acid 125mg). It is used to treat Bacterial Infections affecting the lungs, nose, throat, ears, skin, and urinary tract.
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Avoid consuming alcohol while taking Cefotil Plus 500 Tablet to prevent unpleasant side effects.
Cefotil Plus 500 Tablet should be used with caution in pregnant women only if needed as there are no adequate and well-controlled studies. Consult your doctor before taking it.
Cefotil Plus 500 Tablet is not recommended for use in breastfeeding women as small traces may pass through the mother’s milk. Consult your doctor before taking it.
Dizziness has been reported during treatment with Cefotil Plus 500 Tablet and may affect the ability to drive and use machines. Consult your physician before taking Cefotil Plus 500 Tablet.
Cefotil Plus 500 Tablet should be taken with caution in patients with kidney problems. Consult your doctor for advice.
Cefotil Plus 500 Tablet should be taken with caution in patients with liver problems. Consult your doctor for advice.
Cefotil Plus 500 Tablet is a combination of cefuroxime and clavulanic acid. Cefuroxime works by preventing the formation of bacterial cell walls, thereby stopping the infection to spread. Clavulanic Acid reduces resistance and enhances the activity of Cefuroxime against bacteria. It is a beta-lactamase inhibitor that blocks the action of certain enzymes of bacteria.
Cefotil Plus 500 Tablet is used for the treatment of various bacterial infections such as:
Cefuroxime, the active ingredient in Cefotil Plus 500 Tablet, binds to one or more penicillin-binding proteins (PBPs) in bacterial cells. This binding inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall. Peptidoglycan is an essential component of the bacterial cell wall, and its synthesis is necessary for bacterial cell growth and division.
By inhibiting peptidoglycan synthesis, Cefuroxime disrupts the assembly of the bacterial cell wall, leading to cell wall defects and ultimately bacterial cell death.
Clavulanic acid, another component in Cefotil Plus 500 Tablet, acts as a beta-lactamase inhibitor. Beta-lactamase is an enzyme produced by certain bacteria that can inactivate antibiotics such as Cefuroxime by hydrolyzing their beta-lactam ring, rendering them ineffective against the bacteria.
Clavulanic acid binds to and inhibits specific beta-lactamases, preventing them from degrading Cefuroxime. This combination of Cefuroxime and Clavulanic Acid allows for an extended spectrum of antibacterial activity, as it helps overcome the resistance mechanisms employed by some bacteria, including those resistant to Cefuroxime alone or other penicillins and cephalosporins.
By combining Cefuroxime with Clavulanic Acid, the effectiveness of the antibiotic is enhanced, providing a broader coverage against a wider range of bacteria.
It's important to note that the addition of Clavulanic Acid is specifically aimed at inhibiting beta-lactamase-producing bacteria and does not directly contribute to the primary mechanism of action of Cefuroxime in inhibiting cell wall synthesis.
Adult Dose:
Child Dose (3 months to 12 years):
It's important to note that these dosages are general recommendations and may vary depending on the specific condition, severity, and individual patient factors. Always follow the dosage instructions provided by your doctor or healthcare professional for your specific situation.
Drug-Drug Interactions:
Drug-Food Interactions: No significant interactions between Cefotil Plus 500 Tablet 6's and food have been reported.
Drug-Disease Interactions:
Hypersensitivity to cephalosporins.
It is generally recommended to avoid antibiotics, including cefuroxime-clavulanic acid, if possible during the first trimester of pregnancy due to the potential risks to the developing fetus. However, in later stages of pregnancy, cefuroxime-clavulanic acid may be considered safe for the treatment of certain infections, under the supervision of a healthcare professional.
Cefuroxime-clavulanic acid is excreted in small amounts in breast milk. While there is a possibility of the newborn being sensitized to the medication, the decision to use cefuroxime-clavulanic acid while breastfeeding should be made in consultation with a doctor, considering the potential benefits and risks to both the mother and the infant.
It's important for pregnant or breastfeeding women to consult their healthcare provider for personalized advice and guidance regarding the use of any medication, including cefuroxime-clavulanic acid.
Store Cefotil Plus 500 Tablet at room temperature, protected from light and moisture. Keep out of reach of the children and pets.
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