Cefotil Plus | 500mg+125mg | View Uses, Price, Discounts | ePharma
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Cefotil Plus 500mg Tablet

Generic: Cefuroxime + Clavulanic Acid

Type: Tablet

Pack Size: 12s

Cefotil Plus 500 Tablet is an antibiotic consisting of (Cefuroxime Axetil 500mg + Clavulanic Acid 125mg). It is used to treat Bacterial Infections affecting the lungs, nose, throat, ears, skin, and urinary tract.


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Discount Price: ৳ 338.4
MRP: ৳ 360 6% Off

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✅ Description:

  • Cefotil Plus 500mg Tablet is used for the treatment of various bacterial infections, including urinary tract infections, lower respiratory tract infections, pyelonephritis, uncomplicated gonorrhea, and Lyme disease in adults and children above 12 years of age.
  • Cefotil Plus 500mg Tablet belongs to the cephalosporin class of antibiotics. It works by binding to the outer layer of bacteria, inhibiting the enzyme responsible for peptidoglycan synthesis. This disrupts the bacterial cell wall formation, leading to bacterial cell death.
  • Take Cefotil Plus 500mg Tablet only as prescribed by your doctor. It is available in various forms, such as oral tablets, dispersible tablets, and oral suspension. Complete the full course of treatment as directed by your doctor, even if you start feeling better before finishing the course.
  • Mild and transient side effects may occur, including headache, dizziness, stomach upset, fungal skin infections (candida), unpleasant taste in the mouth, diaper rashes, and increased disease-fighting white blood cells (eosinophilia). Most of these side effects resolve on their own but inform your doctor if they persist.
  • Overdose of Cefotil Plus 500mg Tablet can lead to cerebral irritation and convulsions. It is important to take the medication as prescribed and seek immediate medical attention if an overdose is suspected.
  • There is limited clinical evidence of the effects of Cefotil Plus 500mg Tablet during pregnancy. Use caution and consult your doctor if you are pregnant. Cefotil Plus 500mg Tablet is excreted in breast milk, so nursing mothers should use it cautiously.
  • Cefotil Plus 500mg Tablet should not be taken by individuals who are allergic or hypersensitive to Cefotil Plus 500 Tablets, penicillin, or other beta-lactam antibiotics. If you have a known allergy, inform your doctor before starting the medication.
  • Diarrhea and abdominal cramps may occur during the initial stages of treatment due to disruption of gut flora. Your doctor may prescribe prebiotics or probiotics to help restore the balance of beneficial bacteria in your gut.
  • Individuals with liver or kidney impairment should take Cefotil Plus 500mg Tablet with caution. Your doctor may adjust the dosage based on your specific condition.

Safety Advices


Alcohol
UNSAFE

Avoid consuming alcohol while taking Cefotil Plus 500 Tablet to prevent unpleasant side effects.


Pregnancy
CONSULT YOUR DOCTOR

Cefotil Plus 500 Tablet should be used with caution in pregnant women only if needed as there are no adequate and well-controlled studies. Consult your doctor before taking it.


Breastfeeding
UNSAFE

Cefotil Plus 500 Tablet is not recommended for use in breastfeeding women as small traces may pass through the mother’s milk. Consult your doctor before taking it.


Driving
CAUTION

Dizziness has been reported during treatment with Cefotil Plus 500 Tablet and may affect the ability to drive and use machines. Consult your physician before taking Cefotil Plus 500 Tablet.


Kidney
CAUTION

Cefotil Plus 500 Tablet should be taken with caution in patients with kidney problems. Consult your doctor for advice.


Liver
CAUTION

Cefotil Plus 500 Tablet should be taken with caution in patients with liver problems. Consult your doctor for advice.

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✔️ Uses of Cefotil Plus 500 Tablet
  • Bacterial Infections
✔️ How does Cefotil Plus 500 Tablet work?

Cefotil Plus 500 Tablet is a combination of cefuroxime and clavulanic acid. Cefuroxime works by preventing the formation of bacterial cell walls, thereby stopping the infection to spread. Clavulanic Acid reduces resistance and enhances the activity of Cefuroxime against bacteria. It is a beta-lactamase inhibitor that blocks the action of certain enzymes of bacteria.

✔️ Side Effects of Cefotil Plus 500 Tablet
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
✔️ Quick Suggestions:
  • You have been prescribed this combination medicine to treat bacterial infections, even if they have developed resistance.
  • Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection come back and harder to treat.
  • Take it with food to avoid an upset stomach.
  • Diarrhea may occur as a side effect. Taking probiotics may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
  • Stop taking Cefotil Plus 500 Tablet and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat, or tongue, or breathing difficulties while taking it.
  • Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.
✔️ Indication of Cefotil Plus 500 Tablet

Cefotil Plus 500 Tablet is used for the treatment of various bacterial infections such as:

  • Pharyngitis and/or tonsillitis
  • Acute bacterial otitis media
  • Acute bacterial maxillary sinusitis
  • Lower respiratory tract infections including pneumonia
  • Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis
  • Skin and skin structure infections
  • Urinary tract infections
  • Bone and joint infections
  • Gonorrhoea (uncomplicated and disseminated gonococcal infections)
  • Early Lyme disease (erythema migrans)
  • Septicemia
  • Meningitis
  • Switch therapy (injectable to oral) after surgery when the patient’s condition is improved
✔️ Pharmacology

Cefuroxime, the active ingredient in Cefotil Plus 500 Tablet, binds to one or more penicillin-binding proteins (PBPs) in bacterial cells. This binding inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall. Peptidoglycan is an essential component of the bacterial cell wall, and its synthesis is necessary for bacterial cell growth and division.

By inhibiting peptidoglycan synthesis, Cefuroxime disrupts the assembly of the bacterial cell wall, leading to cell wall defects and ultimately bacterial cell death.

Clavulanic acid, another component in Cefotil Plus 500 Tablet, acts as a beta-lactamase inhibitor. Beta-lactamase is an enzyme produced by certain bacteria that can inactivate antibiotics such as Cefuroxime by hydrolyzing their beta-lactam ring, rendering them ineffective against the bacteria.

Clavulanic acid binds to and inhibits specific beta-lactamases, preventing them from degrading Cefuroxime. This combination of Cefuroxime and Clavulanic Acid allows for an extended spectrum of antibacterial activity, as it helps overcome the resistance mechanisms employed by some bacteria, including those resistant to Cefuroxime alone or other penicillins and cephalosporins.

By combining Cefuroxime with Clavulanic Acid, the effectiveness of the antibiotic is enhanced, providing a broader coverage against a wider range of bacteria.

It's important to note that the addition of Clavulanic Acid is specifically aimed at inhibiting beta-lactamase-producing bacteria and does not directly contribute to the primary mechanism of action of Cefuroxime in inhibiting cell wall synthesis.

✔️ Dosage & Administration of Cefotil Plus 500 Tablet

Adult Dose:

  • Pharyngitis or Tonsillitis: 250 mg twice daily for 5-10 days
  • Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days
  • Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily for 10 days
  • Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily for 5-10 days
  • Community-acquired pneumonia: 250-500 mg twice daily for 5-10 days
  • Uncomplicated skin and skin-structure infections: 250-500 mg twice daily for 10 days
  • MDR Typhoid fever: 500 mg twice daily for 10-14 days
  • Uncomplicated urinary tract infection: 250 mg twice daily for 7-10 days
  • Uncomplicated gonorrhea: 1000 mg as a single dose
  • Lyme disease: 500 mg twice daily for 20 days

Child Dose (3 months to 12 years):

  • Pharyngitis or Tonsillitis: 20 mg/kg/day in two divided doses for 5-10 days
  • Acute otitis media: 30 mg/kg/day in two divided doses for 10 days
  • Acute bacterial maxillary sinusitis: 30 mg/kg/day in two divided doses for 10 days
  • Community-acquired pneumonia: 30 mg/kg/day in two divided doses for 5-10 days
  • MDR Typhoid fever: 30 mg/kg/day in two divided doses for 10-14 days
  • Uncomplicated skin and skin-structure infections: 30 mg/kg/day in two divided doses for 10 days
  • Uncomplicated urinary tract infection: 20 mg/kg/day in two divided doses for 7-10 days

It's important to note that these dosages are general recommendations and may vary depending on the specific condition, severity, and individual patient factors. Always follow the dosage instructions provided by your doctor or healthcare professional for your specific situation.

✔️ Interaction

Drug-Drug Interactions:

  • Antacids (esomeprazole, omeprazole): Concurrent use of antacids may decrease the absorption of Cefotil Plus 500 Tablet. It is advisable to separate the doses of these medications by at least two hours.
  • Anticoagulants (warfarin): Cefotil Plus 500 Tablet may enhance the effect of anticoagulants, leading to an increased risk of bleeding. Close monitoring of bleeding parameters is recommended when using these medications together.
  • Anti-gout medication (probenecid): Probenecid may interfere with the elimination of Cefotil Plus 500 Tablet from the body, leading to increased levels and potential side effects. Dose adjustment may be necessary.
  • Diuretics (furosemide): Concurrent use of diuretics and Cefotil Plus 500 tablets may increase the risk of kidney damage. Close monitoring of kidney function is advised.
  • Oral contraceptives (estrogen, progesterone): Cefotil Plus 500 Tablet 6's may reduce the effectiveness of oral contraceptives. Additional or alternative contraceptive methods may be necessary during treatment with Cefotil Plus 500 Tablet 6's.

Drug-Food Interactions: No significant interactions between Cefotil Plus 500 Tablet 6's and food have been reported.

Drug-Disease Interactions:

  • Colitis: Cefotil Plus 500 Tablet 6's should be used with caution in patients with a history of colitis or inflammation of the colon, as it may worsen the condition.
  • Seizures: Patients with a history of seizures should be closely monitored while taking Cefotil Plus 500 Tablet 6's, as it may lower the seizure threshold.
  • Dialysis, kidney, and liver dysfunction: Dose adjustment may be necessary for patients with kidney or liver dysfunction or those undergoing dialysis. Close monitoring of kidney and liver function is recommended.
✔️ Contraindications

Hypersensitivity to cephalosporins.

✔️ Pregnancy & Lactation

It is generally recommended to avoid antibiotics, including cefuroxime-clavulanic acid, if possible during the first trimester of pregnancy due to the potential risks to the developing fetus. However, in later stages of pregnancy, cefuroxime-clavulanic acid may be considered safe for the treatment of certain infections, under the supervision of a healthcare professional.

Cefuroxime-clavulanic acid is excreted in small amounts in breast milk. While there is a possibility of the newborn being sensitized to the medication, the decision to use cefuroxime-clavulanic acid while breastfeeding should be made in consultation with a doctor, considering the potential benefits and risks to both the mother and the infant.

It's important for pregnant or breastfeeding women to consult their healthcare provider for personalized advice and guidance regarding the use of any medication, including cefuroxime-clavulanic acid.

✔️ Precautions & Warnings
  • Allergy and pre-existing conditions: Inform your doctor if you have any allergies, especially to antibiotics, as well as kidney or liver problems before starting Cefotil Plus 500 Tablet 6's. Also, consult your doctor if you have colitis (inflammation of the colon).
  • Self-medication: Avoid self-medication with Cefotil Plus 500 Tablet, as it can contribute to antibiotic resistance. Always consult your doctor before taking antibiotics.
  • Concurrent treatment: If you are receiving concurrent treatment with potent diuretics, use Cefotil Plus 500 Tablet 6's with caution. Inform your doctor about all the medications you are taking.
  • Pregnancy and breastfeeding: Consult your doctor before taking Cefotil Plus 250 Tablet 6's if you are pregnant or planning for pregnancy. Avoid taking Cefotil Plus 500 Tablet 6's if you are breastfeeding, as it may pass into breast milk.
  • Alcohol and tobacco: Avoid alcohol consumption while taking Cefotil Plus 500 Tablet 6's, as it may cause unpleasant side effects. Additionally, it is advised to avoid tobacco usage.
✔️ Storage Conditions

Store Cefotil Plus 500 Tablet at room temperature, protected from light and moisture. Keep out of reach of the children and pets.

Frequently Asked Questions (FAQ)

No, it is a prescribed drug, given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side-effects.

Depending upon the severity of your medical condition your doctor may prescribe it to you daily for a specific duration. The usual dose of Cefotil Plus 500 Tablet is 7 days (5-10 days), but depending on your current infection state your doctor may extend your dose intake for more days.

After taking an antibiotic you may need to wait for up to three hours for eating or drinking any dairy products include milk as well as butter, yoghurt, and cheese. Grapefruit juice and dietary supplements containing minerals like calcium may also work dampen the effect of antibiotics.

Yes. Cefotil Plus 500 Tablet may interact with birth control pills and lowers its efficiency. So, you should tell your doctor if your are using any birth control pills.

Cefotil Plus 500 Tablet is not recommended for use in children under 3 months of age, as the safety and efficacy of Cefotil Plus 500 Tablet have not been established in this group. Consult your physician for advice before taking
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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